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The sources cited below consist of evidence from peer-reviewed journals, prominent medical organizations, academic associations, and government data. The information contained on this site is for informational purposes only, and should not be used as a substitute for the advice of a professional health care provider.
Please check with the appropriate physician regarding health questions and concerns. Although we strive to deliver accurate and up-to-date information, no guarantee to that effect is made. If you have ever shopped for health, beauty or cleaning items, chances are you have stumbled upon hydrogen peroxide H2O2.
Found in such products as chlorine-free bleaches, contact lens disinfectant solutions, fabric stain removers, first aid wound treatments or "hyper-oxygenation therapy" treatments, H2O2 has unquestionable usefulness in daily life. Yet scientific literature shows that it can also have damaging effects on various organs, including the heart. Whenever they come into contact with organic matter, ROS strongly react and decompose into oxygen and water.
What makes hydrogen peroxide stand out among ROS, however, is its relative chemical stability, small size and the fact that it easily crosses biological membranes. Simply put, it doesn't take long for your body to feel the effects of hydrogen peroxide, especially when it is present in high doses. Many effects of hydrogen peroxide can cause cardiac dysfunction 2. They do not remember when they wake up. This is more likely to happen if you take zolpidem with alcohol, or medicines for mental health problems like depression or anxiety.
This is because your body gets used to this medicine quickly. After taking it for a few weeks, it's unlikely to have the same effect. Your body can also become dependent on it. If you still have problems sleeping after you finish your course of zolpidem, try the lifestyle changes recommended below. They can help you come off your medicine gradually if you have been taking it for a long time, or if you're worried about becoming dependent on it.
Zolpidem should only be used short term usually up to 4 weeks for sleep problems. This is because your body can become dependent on it. See a doctor if you feel you need to take it for longer than 4 weeks.
They will be able to discuss your sleep problems and recommend other things that may help. If you have been taking zolpidem for longer than 4 weeks, do not stop taking this medicine suddenly. You may get withdrawal symptoms. Your insomnia can come back and it may be worse than before. You may also feel anxious, restless and have mood changes. You may become very sensitive to light, noise and being touched.
Speak to the doctor first about coming off zolpidem. They may recommend reducing your dose of zolpidem slowly, over a few days or weeks. This will help prevent withdrawal symptoms if you've been taking it for more than 4 weeks. If zolpidem makes you sleepy, dizzy or clumsy, gives you blurred vision or you cannot concentrate or make decisions, do not drive a car, ride a bike or operate machinery.
This may be more likely when you first start taking zolpidem, but could happen at any time — for example, when starting another medicine. It's an offence to drive a car if your ability to drive safely is affected. It's your responsibility to decide if it's safe to drive. If you're in any doubt, do not drive. UK has more information on the law on drugs and driving. Talk to a doctor or pharmacist if you're unsure whether it's safe for you to drive while taking zolpidem.
There's no firm evidence to suggest that taking zolpidem will reduce fertility in either men or women. But speak to a pharmacist or doctor if you and your partner are trying for a baby. Your doctor may review your treatment. Zolpidem does not affect how contraception works, including the combined pill and emergency contraception.
Do not have drinks that contain caffeine while you're on zolpidem. These include coffee, tea, cola and energy drinks and hot chocolate. Alcohol and zolpidem together can make you sleep very deeply, so you do not breathe properly and can have difficulty waking up. If this happens to you, do not do any activities that require you to be fully alert, such as driving, cycling, or using tools or machinery.
Using cannabis with zolpidem will make its sleep-inducing sedative effects worse. You could go into a very deep sleep, where you have difficulty waking up.
Using heroin or methadone with zolpidem may also increase the sedative effects of both drugs. Zolpidem increases the activity of GABA. GABA is a chemical in your body that causes sleepiness. Increasing its activity helps you fall asleep. Zolpidem can cause mild or serious side effects. The following list contains some of the key side effects that may occur while taking zolpidem.
This list does not include all possible side effects. For more information on the possible side effects of zolpidem, or tips on how to deal with a troubling side effect, talk with your doctor or pharmacist.
If these effects are mild, they may go away within a few days or a couple of weeks. Call your doctor right away if you have serious side effects. Serious side effects and their symptoms can include the following:. Zolpidem oral tablet can interact with several other medications.
Different interactions can cause different effects. For instance, some can interfere with how well a drug works, while others can cause increased side effects. Below is a list of medications that can interact with zolpidem. This list does not contain all drugs that may interact with zolpidem. Before taking zolpidem, be sure to tell your doctor and pharmacist about all prescription, over-the-counter, and other drugs you take. Also tell them about any vitamins, herbs, and supplements you use.
Sharing this information can help you avoid potential interactions. If you have questions about drug interactions that may affect you, ask your doctor or pharmacist. Taking zolpidem with certain medications raises your risk for side effects. This is because zolpidem and these other medications can cause the same side effects. As a result, these side effects can be increased. Examples of these drugs include:. Taking zolpidem with certain medications raises your risk for side effects from zolpidem.
This is because the amount of zolpidem in your body may be increased. When zolpidem is used with certain drugs, it may not work as well to treat your condition.
This is because the amount of zolpidem in your body may be decreased. The following information describes dosages that are commonly used or recommended. However, be sure to take the dosage your doctor prescribes for you.
Your doctor will determine the best dosage to suit your needs. The liver of an older adult may not work as well as it used to.
This can cause your body to process drugs more slowly. As a result, more of a drug stays in your body for a longer time. This raises your risk for side effects.
Your doctor may start you on a lowered dosage or a different treatment schedule. This can help keep levels of this drug from building up too much in your body. This may cause trouble driving. This drug may cause changes in behavior, such as increased agitation.
You may act differently. Symptoms can include muscle cramps, vomiting, sweating, flushing reddening and warming of your skin , and emotional changes. You will probably become very sleepy soon after you take zolpidem and will remain sleepy for some time after you take the medication.
Plan to go to bed right after you take zolpidem tablets, extended-release tablets, sublingual tablets Edluar , and oral spray and to stay in bed for 7 to 8 hours. Take zolpidem sublingual tablets Intermezzo only when you are already in bed and can remain in bed for at least 4 more hours. Do not take zolpidem if you will be unable to remain asleep for the required number of hours after taking the medication.
If you get up too soon after taking zolpidem, you may experience drowsiness and problems with memory, alertness, or coordination. Swallow the extended-release tablets whole; do not split, chew, or crush them. Tell your doctor or pharmacist if you cannot swallow tablets.
Do not open the pouch that contains the sublingual tablet Intermezzo until you are ready to take the tablet. To remove the sublingual tablet Edluar from the blister pack, peel off the top layer of paper and push the tablet through the foil. To take either brand of sublingual tablet, place the tablet under your tongue, and wait for it to dissolve. Do not swallow the tablet whole or take the tablet with water.
Your sleep problems should improve within 7 to 10 days after you start taking zolpidem. Call your doctor if your sleep problems do not improve during this time or if they get worse at any time during your treatment. Zolpidem should normally be taken for short periods of time. If you take zolpidem for 2 weeks or longer, zolpidem may not help you sleep as well as it did when you first began to take the medication.
Talk to your doctor about the risks of taking zolpidem for 2 weeks or longer. Zolpidem may be habit forming. Do not take a larger dose of zolpidem, take it more often, or take it for a longer time than prescribed by your doctor. Do not stop taking zolpidem without talking to your doctor, especially if you have taken it for longer than 2 weeks. If you suddenly stop taking zolpidem, you may develop unpleasant feelings or mood changes or you may experience other withdrawal symptoms such as shakiness, lightheadedness, stomach and muscle cramps, nausea, vomiting, sweating, flushing, tiredness, uncontrollable crying, nervousness, panic attack, difficulty falling asleep or staying asleep, uncontrollable shaking of a part of your body, and rarely, seizures.
You may have more difficulty falling asleep or staying asleep on the first night after you stop taking zolpidem than you did before you started taking the medication. This is normal and usually gets better without treatment after one or two nights. Your doctor or pharmacist will give you the manufacturer's patient information sheet Medication Guide when you begin treatment with zolpidem and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions.
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information. This medication is taken as needed. You may take zolpidem even if it is later than the usual time, as long as you will be able to remain in bed for the required number of hours after you take it. Zolpidem may cause other side effects.
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