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Methods Generalized tetanus was produced in seven adult white rabbits by injecting 15 mouse-test doses of tetanus toxin into the subcutaneous tissue of the back. One day later one of these rabbits was made completely flaccid for ten hours by administration of the neuromuscular blocking agent, succinylcholine. During the succinylcholine-induced paralysis, a tracheostomy was performed under local anesthesia induced by procaine, and respirations were maintained with a pump ventilator.
The succinylcholine, as well as fluids and glucose, was administered by continuous intravenous infusion. The CPK activity was measured by the method of Tanzer.
Arch Neurol. Coronavirus Resource Center. Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy Continue. Twitter Facebook Email. This Issue. January Save Preferences. Privacy Policy Terms of Use. Sign in to access your subscriptions Sign in to your personal account. Institutional sign in: OpenAthens Shibboleth. It is rapidly cleared with a half-life of about 2 hours. Muscle diseases are the main source of plasma CK elevations: inherited myopathies, malignant hyperthermia, hypothyroidism, vitamin E-selenium deficiency, prolonged decubitus, intramuscular injections, surgery, etc.
Plasma CK is also increased in experimental myocardial infarction, for which the dog is an interesting model, allowing quantification of the damage by measuring the total CK activity released.
Abstract In the dog, creatine kinase CK is mostly present in the skeletal muscles, myocardium, brain and intestine. Publication types Review.
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