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The following safer sex practices can also lower the chances of passing genital herpes to a partner: --Use a condom made of latex or polyurethane when you have sexual contact. The study was conducted among about monogamous, heterosexual couples and lasted eight months. At the beginning of the study, only one member in each couple had evidence of genital herpes.
Valtrex may cause kidney problems in some people. In addition, Valtrex may cause nervous system problems; these include aggressive behavior, unsteady movements, shaky movements, confusion, speech problems, hallucinations, seizures and coma.
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Therapeutic Vaccines. Bacterial Enteric Infections. Valtrex valacyclovir HCl Profile. Profile Contact Information. Currently Enrolling Trials Show More. General Information Valtrex has been approved as a treatment for recurrent genital herpes herpes simplex in otherwise healthy immunocompetent adults. Side Effects Valtex was generally well tolerated, with the most common adverse events consisting of headache, nausea, diarrhea, and dizziness.
Mechanism of Action Valtrex is rapidly and extensively converted to acyclovir after oral administration. In addition, suppressive therapy with Valtrex reduced the risk of overall acquisition of the virus with or without symptoms confirmed with a lab test by 48 percent versus placebo 1. Throughout the eight-month study, all couples were counseled on safer sex practices at all study visits and encouraged to use condoms.
The principles of safer sex practices were 1 to avoid sexual contact when the infected partner had any symptoms of genital herpes and 2 consistent and correct use of condoms during all sexual contacts. In addition, Valtrex significantly reduced the number of recurrences in the infected partner versus placebo, consistent with previous studies. The most commonly reported side effects in the study were headache Valtrex 29 percent, placebo 26 percent , nasopharyngitis Valtrex 16 percent, placebo 15 percent , and upper respiratory infection Valtrex 9 percent, placebo 10 percent.
The effect of Valtrex on transmission of genital herpes has not been established in immunocompromised individuals or same-sex couples. The effect of Valtrex on reducing transmission beyond eight months has not been established.
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