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Just give us a call or fill out the Online Appointment Request form below. Virtual Assistant. If you would like us to call you to set up an appointment, please click here to request a call back. If you would like to call us, please call to speak with a representative. Our hours are:. Elevated PSA can indicate a number of conditions. Find a Location physician-name. Find a Physician physician-name. Excluding skin cancer, prostate cancer is the most common cancer in men 1 in 8 lifetime risk , accounting for about one-quarter of newly diagnosed cancers in males.
An elevated or accelerated PSA that leads to prostate biopsy and a cancer diagnosis most often detects prostate cancer in its earliest and most curable state. Early and timely intervention for men with aggressive cancer results in high cure rates and avoids the potential for cancer progression and consequences that include painful cancer spread and death.
The upside of screening is the detection of potentially aggressive prostate cancer that can be treated and cured. The downside is the over-detection of unaggressive prostate cancers that may never prove to be problematic, but may result in unnecessary treatment with adverse consequences.
The downside of not screening is the under-detection of aggressive prostate cancers, with adverse consequences from necessary treatment not being given. How is PSA used to screen for prostate cancer?
Baseline PSA testing for men in their 40s is useful for predicting the future potential for prostate cancer.
In a recent study of , men with an average age of 55, median PSA was 1. Why is PSA elevated in the presence of prostate cancer? Prostate cancer cells do not make more PSA than normal prostate cells. The elevated PSA occurs because of a disruption of the cellular structure of the prostate cells.
The loss of this structural barrier allows accelerated seepage of PSA from the prostate into the blood circulation. There is no letter C for cancer in PSA. Not all PSA elevations imply the presence of prostate cancer. PSA is prostate organ -specific but not prostate cancer -specific. Other processes aside from cancer can cause enhanced seepage of PSA from disrupted prostate cells.
These include prostatitis inflammation of the prostate , benign prostatic hyperplasia BPH, an enlargement of the prostate gland , prostate manipulation e. Why is PSA not a perfect screening test? PSA screening is imperfect because of false negatives presence of prostate cancer in men with low PSA and false positives absence of prostate cancer in men with high PSA. Despite its limitations, PSA testing has substantially reduced both the incidence of metastatic disease and the death rate from prostate cancer.
How is PSA used in men diagnosed and treated for prostate cancer? Conditions We Treat. Patient Guide. PSA Test Timetable. Age For all men who do not have major health problems. Test Results and What They Mean. There is no specific normal or abnormal level of PSA in the blood. In the past, most doctors considered PSA levels of 4. However, more recent studies have shown that some men with PSA levels below 4. Various factors can cause a man's PSA level to fluctuate, ranging from having a urinary tract infection to taking medication to treat BHP.
Although expert opinions vary, there is no clear consensus regarding the optimal PSA threshold for recommending a prostate biopsy for men of any racial or ethnic group. In general, the higher a man's PSA level, the more likely it is that he has prostate cancer. Moreover, continuous rise in a man's PSA level over time may also be a sign of prostate cancer.
A prostate gland biopsy A resection of the prostate Rigorous physical activity related to the prostate i. Resources at Cedars-Sinai.
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